Reuse of public, genome-wide, murine eosinophil expression data for hypotheses development
نویسندگان
چکیده
منابع مشابه
Genome-wide prediction of imprinted murine genes.
Imprinted genes are epigenetically modified genes whose expression is determined according to their parent of origin. They are involved in embryonic development, and imprinting dysregulation is linked to cancer, obesity, diabetes, and behavioral disorders such as autism and bipolar disease. Herein, we train a statistical model based on DNA sequence characteristics that not only identifies poten...
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Learning latent “expression themes” that best express complex patterns in a sample is a central problem in data mining and scientific research. For example, in computational biology we seek a set of salient gene expression themes that explain a biological process, extracting them from a large pool of gene expression profiles. In this paper, we introduce probabilistic models to learn such latent...
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Bacillus clausii TnrA transcription factor is required for global nitrogen regulation. In order to obtain anoverview of gene regulation by TnrA in B. clausii KSMK16, the entire genome of B. clausii was screened forthe consensus sequence, 5’-TGTNAN7TNACA-3’ known as the TnrA box, and 13 transcription units werefound containing a putative TnrA box. The TnrA targets identified in...
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BACKGROUND Recently, gene expression levels have been shown to demonstrate familial aggregation, suggesting a direct role of heritable DNA variation. We studied the gene expression levels in lymphoblastoid cells of the Centre d'Etude du Polymorphisme Humain Utah families made available to Genetic Analysis Workshop 15 (GAW15), using genome-wide linkage analyses. METHODS Heritability was estima...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2018
ISSN: 0741-5400
DOI: 10.1002/jlb.1ma1117-444r